What I've been thinking about...
This idea has cropped up on a couple of the radio shows I listen to lately. Open Dyslexic is a Font designed to make things easier for dyslexic readers.
The bottom-heavy look is designed to discourage mentally rotating or flipping letters. Shapes of commonly mistaken letters (like “i” and “j” for instance) are also made more distinct to avoid confusion.
The shows I listen to were full of rave reviews from users. With a quick search, the only academic review I could find involved a study with 21 participants, and the numbers of errors was indeed reduced when this font was used.
On the balance, there’s no downside because Open Dyslexic is open source. If you know anyone that might benefit, you may want to send them a link! Check out their site, and find downloads at dyslexicfonts.com.